Multi Plate Shaker - MPS-1

Multiplate shaker MPS-1 can be used in virtually any application.

It provides adjust-able mixing of reagents in microplates, PCR and deep well plates. It shakes test tubes with volumes from 0.3 to 2 ml and pre-text any volume up to 50 ml. In addition, it is equipped with a head also for vortexing a single tube.

Shaker can be operated in cold rooms or incubators at a room temperature of +4°C to +40°C.
The external low voltage power supply (12 V) provides safety in humid environments.

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High-Speed Multi Plate Shaker

Speed control range 300–3,200 rpm
Smooth mixing with 3 mm orbit
Mixing presets
Pulse Mode mixing function
Quiet operation — low noise at maximum speed
High stability — stationary at maximum speed
Universal platform holder for Deepwell plates and Microtest plates
Additional platforms for semi- and unskirted PCR plates as well as for tubes from 0.2 to 2 ml
Can be used in cold rooms or incubators (temperature range +4°C to +40°C)

Special Feature - Pulse Mode

MPS-1 features Pulse Mode mixing function that works on the principle of giving a periodic impulse. The tube is accelerated to the set speed, holds it for 3 seconds and then drops the speed to zero. This motion is repeated until the timer runs out.

This method provides a constant state of resuspension of the particles inside a tube, as the acceleration is always changing. The advantage of this method is the high throughput of mixed samples compared to vortexing a single tube.

Order No. Shaker MPS-1 with built-in universal platform Set of four platforms inclusive (P-02/96, P-2/24, P-05/32, P-02/05)	105.1220
Types of Mixing Presets
VORTEX	3200 rpm
HARD	2600 rpm
MEDIUM	1800 rpm
SOFT	1000 rpm
CUSTOM	adjustable rpm
General Technical Data
Pulse Mode Mixing	yes
Vortex	yes
Maximunm load	0.3 kg
Orbit	3 mm
Acceleration time to maximum speed	5 s
Digital time setting	0 – 60 min (15 s increment) / non-stop
Maximum continuous operation	8 h
Noise level, not more	65 dB
Weight	5.1 kg
Overall dimensions (W × D × H)	225 × 215 × 150 mm
Input current/ power consumption	12 V, 800 mA / 10 W
External power supply	Input AC 240 V, 50/60 Hz, Output DC 12 V

Complete Set – Multi Plate Shaker MPS-1

The universal platform and the vortex are built-in the unit.

Additional platforms (in blue) are included in the delivery of the plate shaker MPS-1.

	P-2/24	Platform for 24 x 1.5 – 2 ml tubes
	P-05/32	Platform for 32 x 0.5 ml tubes
	P-02/05	24 x 0.5 ml and 48 x 0.2 ml tubes
	P-02/96	Platform for 96 x 0.2 ml tubes or semi-/unskirted PCR plates
Example applications
	Universal platform	Suitable for deep well plates: 96/1000 µl
	Universal platform	Suitable for deep well plates: 96/500 µl
	Universal platform	Suitable for microtest plates: 200 µl
	Vortex	For 50 ml tubes
	Vortex	For 15 ml tubes

Why do we need new mixing principle in biotechnology - in fact there already are various shakers for flasks, disposable bags with wave mixing technology, falcon tubes with permeable gas membranes and bioreactors with various mixing principles?

You are correct, in reality, there are many types of reaction vessels and bioreactors that the market can offer for the cultivation of microorganisms, yet we think that RTS technology has its unique niche.

The most important issue when choosing a bioprocess technology is whether it is scalable. The impossibility of direct transfer of optimal conditions from thermoshakers to bioreactors became a common issue. Many engineers are in search for the middle ground, which is so that the cultivation in the bioreactor would be as simple and accessible as in shaker flasks and so that the process could be carried out in parallel from one hand, and on the other hand so that the bioprocess would be scalable. Lower aeration values using shaker flasks in comparison to bioreactors or, in other words, low oxygen mass transfer into the culture medium does not allow getting as high cell densities as quickly as possible like in bioreactors.

What other noninvasive mixing principles that are available on the market today?

As can be observed from image. Biosan produces most of devices for noninvasive mixing which in turn can be used for bioprocesses. Moreover, we would like to introduce a new mixing principle into this table called Reverse Spinning. In the future, we will develop multi-channel RTS devices with higher and smaller volumes. In our estimates, the mixing technology can be scaled up to 20 litres and scaled down to 5ml. With a possibility to add vital bioprocess parameters noninvasive measurement such as pH and pO_2.

What is the mixing principle of RTS technology devices?

Initiation of the Vortex Type Mixing (VTM) and depth of the Vortex cave depend on 1) angular speed of RS–Reactor 2) time from initiating rotation of RS–Reactor 3) growth media viscosity 4) temperature. These parameters, also, determine the angular speed of rotating Vortex Layer (VL) and transition state from the Irrotational Vortex (IRV), when angular speed of the VL is proportional to the radius, to the Rotational Vortex, when the angular speed of the VL is the same and VL looks like a monolithic Vortex cavity, as shown below. Common rules regulating VTM processes may be stated as follows: the more time has passed since Vortex formation, the more obvious is a transition from IRV to the RV. The concept of the Reverse–Spin (RS) mixing is based on these assumptions.

What is the measurement principle of RTS technology devices?
What is the measurable range of biomass in OD600nm units?

The essential elements of RTS-1 measurement system consist, as shown below, of a light source, a detector (photodiode), a falcon tube compartment in a rotating state. The falcon tube accelerates to 2000 min^-1creating a monolayer of cell suspension shortening the optical path of the sample. By shortening the optical path, it is possible to measure biomass in the range of 0-19 OD_600nmat 10-20ml and 0-15.2 OD_600nmat 10-30ml.